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Whilst B12 injections have a well-established clinical role in treating deficiency states such as pernicious anaemia, malabsorption syndromes, and certain dietary deficiencies, lipotropic injections lack the same evidence base and regulatory approval

In one study, among patients with non-small cell lung cancer treated with anti-PD-1/PD-L1, those who received corticosteroids to manage their irAE had reduced clinical benefit from immunotherapy, with shorter progression-free survival and overall survival

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The failure nodes include: Gut inflammation & dysbiosis Excess DPP-4mediated GLP-1 degradation Insulin resistance Impaired vagalbrain signaling Mitochondrial dysfunction in L-cells Ayurvedic translation (systems concordance) GLP-1 dysfunction maps precisely to: Agnimandya (low digestivemetabolic fire) Ama accumulation (metabolic toxins) KaphaMeda dushti (obesity, insulin resistance) PranaSamana Vata imbalance (gutbrain satiety failure) Advanced stage: Madhumeha Ayurveda predicted GLP-1 logic thousands of years ago through the AgniAmaKapha axis

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