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In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Daneman and Prat, 2015

In addition, glutamine has been confirmed to be a major nutrient source for oxidative metabolism in some cancer cell lines 10,11,12 , and specific genetic interference with glutaminase (GLS) inhibits tumor cell growth 13

Vitamin C is an antioxidant which scavenges free radicals in the body and protects tissues from oxidative stress [10-12,16-20]

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& Rehman, A

Proc Jpn Acad Ser B Phys Biol Sci 85(1):1236 Carbone DL, Doorn JA, Kiebler Z, Petersen DR (2005) Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase