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FITC anti-human lineage cocktail (47, 48): CD3 (UCHT1, Biolegend), CD14 (HCD14, Biolegend), CD16 (3G8, Biolegend), CD19 (HIB19, Biolegend), CD20 (2H7, Biolegend), CD56 (HCD56, Biolegend) CD235a (HI264, Biolegend), FCRIa (AER-37, Biolegend), CD1a (HI149, Biolegend), CD123 (6H6, Biolegend) and CD5 (L17F12, Biolegend)

Randomized participants follow an 8-week dose escalation regimen (3 mg [weeks 04], 7 mg [weeks 48], and 14 mg [weeks 8156])

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PlexusDx providers can evaluate your symptom timeline, meal patterns, and medical history to determine whether slow titration, dietary adjustment, or targeted genetic testing would optimize your treatment experience

The encircled active site, unique to NS5B, is contained within the palm structure of the protein

doi:10.1038/srep06697 Kornelius E, Huang J-Y, Lo S-C, Huang C-N, Yang Y-S