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In Vivo Mouse Intervertebral Disc Degeneration Model Based on a New Histological Classification

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Reports of Biochemistry and Molecular Biology 13:507515

Although clinical trials are limited, the evidence suggests that B12 injections at a dose of at least 500 g three times per week for 2 weeks are effective in relieving chronic low back pain

However, the outcome assessors were blinded to group assignments to minimize detection bias during data collection and analysis