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At the moment, the most accurate answer is that safety has not been fully established in humans

It is made entirely in a lab using solid-phase peptide synthesis a chemical process that builds peptides one amino acid at a time on a polymer resin

FDA's Official Reasons: Lack of Clinical Trials: The FDA emphasizes the need for extensive, controlled clinical trials, which are currently lacking

While both are investigated for their roles in metabolic health and fat management, their fat loss mechanisms differ significantly

Patients using semaglutide often see a reduction in their HbA1c levels of around 1-2%, which is a substantial improvement