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The glucagon component increases energy expenditure and fat oxidation, a mechanism unique to retatrutide that semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP) lack

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Response: We acknowledge commenters' concern regarding the timing around measure removal and the costs of preparing to report on the measures

Our study nally establishes that mito- chondrial GPx4 confers the vital role of selenium in mammalian male fertility and identies cytosolic GPx4 as the only GPx4 isoform being essential for embryonic development and apoptosis regulation.Schneider, M., Fo rster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz, F., Neumu ller, C., Deutsch, M

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10.1016/j.regpep.2012.12.007 7 BecejacT.CesarecV.DrmicD.HirslD.MadzaracG.DjakovicZ.et al (2018)