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The following strategies can help patients tolerate treatment and reduce the likelihood of complications: Gradual dose escalation is fundamental to tolerability

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Example 8 Table no 12: Formulation of batches using Carbopol Ultrez 10 Table no 13: Formulation of batches using Carbopol 971P NF Table no 14: Formulation of batches using Carbopol 974P NF Process of preparation of batches 1-11 is same as that described under example 2 for batch G