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doi: 10.3899/jrheum.110916 213 MizrajiM

This craze exploiting the implication of topical skin Lightening agents and therapies containing hydroquinone, alpha and beta hydroxylases, tretinoin, arbutin, VitaminC serum, soy extract

27 Importantly, GLP-1 action is short-lived, with a half-life of just 12 minutes in the bloodstream under normal physiological conditions, after which it is broken down by the enzyme dipeptidyl peptidase IV (DPP-4), resulting in a loss of its biological activity

The autoimmune reactions caused by immune checkpoint inhibitors appear to be dependent on the pathways targeted, as explained in a paper published in Nature Medicine

Mayeur C, Veuillet G, Michaud M, Raul F, Blottire HM, Blachier F