KpkaASzajdaSDWaszkiewiczNPudowskiPChojnowskaSRudyMet al
Mendelian randomization A method using measured variation in genes (for example, single nucleotide polymorphisms) to examine the causal effect of an exposure on an outcome
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For the estradiol treatment, 0.3 cm silastic estradiol capsules (Baxter HealthCare, Mundeleine, IL, USA) were implanted subcutaneously in the mice
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Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner ( 2.3.2 Immune cell recruitment inhibition Apart from inflammatory cytokines secretion reduction, inhibited macrophage infiltration and immune cell recruitment also played a vital role in GLP-1RAs anti-inflammatory ability
