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Gastroenterology 162 , 743756 (2022)

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TNF- activates multiple signaling pathways through binding to its receptors (TNFR1 and TNFR2), inducing the release of inflammatory mediators, cell proliferation, apoptosis, and immune cell recruitment, ultimately leading to chronic intestinal inflammation

Funding This work was supported by a National Research Foundation of Korea (NRF) grant, funded by the Ministry of Science and ICT of Korea (No

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer