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Targeting FSP1 triggers ferroptosis in lung cancer

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In the present study, elevated PGA levels were observed among 89% of symptomatic TTR-V30M patients and in 63% of asymptomatic carriers relative to the median of healthy controls (Table 1)

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2.3 System Xc - : cystine uptake and biosynthesis of GSH and polysulfides The supply of cysteine, the rate-limiting precursor for GSH, is maintained by the cystine/glutamate antiporter system Xc - , composed of SLC7A11 (also known as xCT) and SLC3A2 [76]

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