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Patients should undergo a formal metabolic assessment prior to any peptide treatment

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A marked colocalization of Rab7 with Arl8b indicates stalling of endolysosomes filled with A aggregates, hindering completion of the autophagic vesicular trafficking

Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly