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In addition, circulating fatty acids were elevated in Ndufs2 KO mice (Fig

Mayo Clinics ENDO 2025 study of 120 postmenopausal women found tirzepatide plus HRT produced 17% weight loss vs 14% alone over 18 months, with 45% of HRT users hitting 20%+ loss vs 18% of non-users (see our tirzepatide vs semaglutide analysis)

This happens because the kidneys are constantly working to filter out the excess acids produced by the condition [1] [2]

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Accordingly, a small study reported increased DNL in NAFLD patients ( n = 5) compared to controls ( n = 6) [38]

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