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It is an immune system malfunction , a barrier defect, and a microbial imbalance happening simultaneously

Specifically, this includes the generation of mtROS, alterations in mitochondrial morphology and function, increased calcium ion uptake, and the regulation of specific genes, all of which collectively contribute to ferroptosis

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flexneri strain rescued with ipaH1.4 but not the ipaH1.4 / ipaH2.5 strain significantly induced the degradation of endogenous RNF213 in host cells (Fig

Makino, T., Ishikawa, K., Igarashi, I., Yamoto, T., Manabe, S., and Nakayama, H

Blood Cancer (2020)