More serious symptoms occur with severely elevated blood levels of homocysteine and include osteoporosis, hip fractures, visual disturbances, kidney disease, hypothyroidism, cognitive decline, and other neurological problems.3 Abnormal blood levels of folate, vitamin B6, and vitamin B12 are also associated with hyperhomocysteinemia
The most common side effects in trials are gastrointestinal: nausea (around 43% at 12 mg), vomiting (21%), and diarrhoea (33%)
It was seen that the most significant rises in tissue glutathione occurred in the high-dose group after about six months
By facilitating Phase 2 liver detoxification, neutralizing the ROS that trigger mast cell degranulation, and protecting the autonomic nervous system from neuroinflammation, glutathione addresses the root metabolic dysfunctions driving these interconnected conditions
*Oral semaglutide 25 mg (Wegovy in a pill) is investigational and not yet approved in the US or EU
A common and easy-to-work-with concentration is 100mg/mL