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At the cellular level, GLP-1 can significantly increase the expression levels of ABCA1 and ABCG1, and decrease the level of intracellular cholesterol, which inhibits the transformation of macrophages into foam cells [72]

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Weight loss remains a central therapeutic driver: A reduction in body weight of at least 7 to 10 percent resolves NASH in approximately 65 to 90 percent of patients

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