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CagriSema treatment resulted in substantially greater and clinically meaningful weight loss (-20.4%) than semaglutide alone (-14.9%), cagrilintide alone (-11.5%), or placebo (-3.0%), a finding consistent with at least partial additivity, although the study design does not permit a formal assessment of additive or synergistic effects

Intramuscular administration is also discussed but is less common for self-administration

Never skip tiers

Inject in a different quadrant each week, cycling through all four before returning to the first

Some patients require a short course to correct deficiency, while others may benefit from maintenance injections over time

By Dani Blum and Roni Caryn Rabin The F.D.A