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Description

Riboflavin, in the form of flavin adenine dinucleotide (FAD), is shown as the required cofactor for this reaction, which consumes NADPH and a proton (H + ) and releases NADP +

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S2), clearly demonstrating that uncatalyzed glutathionylation of regular protein thiols occurs much too slowly at low physiological GSSG concentrations to compete with glutaredoxin-dependent glutathionylation 63

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