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The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review, Biomedicine & Pharmacotherapy

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3.3 Disruption of mitochondrial dynamics and quality control Mitochondria are highly dynamic organelles that undergo constant fission (division) and fusion (merging) to maintain a healthy network

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For this reason, challenges in affinity purification are not only how to optimize methods to obtain highly pure proteins, but also in developing bioinformatic methods to differentiate true protein interactions from background interactions