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Extremely high doses have not been well-studied for long-term safety

Materials and methods Cell culture The human pancreatic cancer cell lines (CFPAC-1, SW1990, PANC-1, and BxPC-3) and murine pancreatic cancer cell line (Pan02) were procured from the Cell Bank of the Chinese Academy of Sciences Type Culture Collection (Shanghai, China)

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The hydrolysis products include goitrin, several isothiocyanates, thiocyanate ions, and nitriles

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Extrapolation from prior data suggests that the final NAC infusion rate should be 12.5 mg/kg/h for patients with APAP concentrations above the 300 mcg/mL line or with ingestions of 32 grams