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There is no indication that long-term use changes this fundamental characteristic

Zinc depletion with prolonged supplementation 2

10.1167/iovs.12-10119 Invest Ophthalmol Vis Sci

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NAC has been used clinically for decades as an FDA-approved drug for acetaminophen overdose (where it replenishes hepatic glutathione) and as a mucolytic agent [18]