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Side effect-limited patients: Those who cannot tolerate higher doses of standard immunosuppressants and need additional inflammatory control without additional immunosuppression

In line with these observations, the treatment of the murine syngeneic PCa and bladder cancer models with the JHU-083 inhibitor led to the reprogramming of the tumor-associated macrophages (TAMs) from an immunosuppressive to inflammatory state and increased TAM proliferation and glycolysis [99]

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