COQ4 mutations have the highest incidence of epilepsy, reaching up to 69%, with a higher prevalence among females
Role of insulin-like growth factor 1 receptor signalling in cancer
2007 Sep 1;137(9):2098-105
MeAIB and -MT SLC38A1 is overexpressed in melanoma, breast cancer, gastric cancer, osteosarcoma, and endometrial cancer cells, while SLC38A2 is overexpressed in prostate cancer, hepatocellular carcinoma (HCC), and TNBC cells [34]
High concentrations of ROS can oxidize mitochondrial proteins, lipids, and nucleic acids, cause cell dysfunction, damage the ability of cells to maintain energy levels, cause energy exhaustion, damage and death of neurons, and change the excitability of neurons, thus reducing the threshold of seizures (6, 7)
The mechanistic consequence is that GHRP-6 activates the full biological program that ghrelin controls not just GH secretion, but somatostatin suppression, appetite signaling via NPY/AgRP pathways, gastric motility, and elements of the reward circuitry
