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Importantly, those effects were observed only in animal and in-vitro models , not in verified human clinical settings
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Due to the low incidence rate of Von Hippel-Lindau syndrome in the population, clinical studies on VHL have been limited to animal studies and retrospective case-control studies, and cohort studies are still needed to further validate the mechanisms involved
It is a high affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively)
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