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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Transdermal estrogen does not increase the risk of venous thromboembolism (118), has a lower risk of cholestasis than the oral route (143), and may be a more amenable form of HRT for people with MASLD, which is supported by the results of 1 observational study (129)

However, it also comes with some gastrointestinal side effects, including nausea and slowed stomach emptying, which can be linked to acid reflux in some people

As the first triple hormone receptor agonist in development, this investigational drug activates three distinct metabolic pathways that single or dual agonists simply cannot address

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