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No formal tolerance study exists, but neuropeptide receptors can downregulate under sustained stimulation

GLP-1s can be quite costly

In general, no

independently extracted the following information from the included meta-analyses: first author, publication year, intervention type, study population, study design, number of included trials, number of participants, outcomes, effect model, effect size, heterogeneity, and publication bias

We applied these assessment criteria consistently to gauge bias risk and internal validity within each study

Semaglutide trials (STEP 1-4) demonstrated 15-22% weight loss over 68 weeks, while tirzepatide (SURMOUNT trials) showed 20-24% weight loss at the highest doses