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Salidroside exhibits relatively rapid absorption following oral administration and demonstrates measurable penetration across the bloodbrain barrier, consistent with its documented central neuroprotective and antidepressant effects
The mechanisms are not fully understood but may involve GLP-1 receptor distribution in the central nervous system, gastrointestinal effects, dehydration, or vascular changes
Longitudinal, multi-modal molecular imaging studies with targeted radiotracers have the potential to elucidate the earliest mechanisms associated with LLD and with subsequent cognitive or motor decline
Chemical structures have been accurately depicted using ChemDraw software (ver 12.0.2
Perhaps for some people there are no AEs, but I think we require more long-term data with better outcomes than aBMD from DXA before we can be confident to conclude these drugs don't adversely impact bone
It's not the desired bedtime, but it's where they are
