Since it is well known that GSH depletion leads to the upregulation of antioxidant genes, many of which are under Nrf2 control and, that in several types of tumors, Nrf2 is constitutively activated [122, 123], a new and indirect approach for cancer therapy may be used to modulate the Nrf2-ARE pathway
doi: 10.1016/j.aquaculture.2022.738483 41 LuthmanO.RobbD
A.YoshidaC
(Standardized to contain 24% Ginkgo Flavone Glycosides)
The results revealed that, except for the metabolic organs liver and kidney, the tumor tissue exhibited the highest fluorescence intensity, further confirming the excellent tumor targeting of NP4 (Fig
Therefore, blocking cystine/glutamate transporters and synergistically inhibiting glutamine metabolism may be an effective strategy for reversing tumor drug resistance and improving therapeutic effects