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Patients with diabetes, cardiovascular disease, or on concurrent medications benefit from deeper evaluation before starting GLP-1 therapy

Semaglutide and tirzepatide, the most commonly used compounds, begin at the lowest dose and increase incrementally

Even at low doses, these medications carry risks including pancreatitis (requiring discontinuation if suspected), gallbladder disease, and rare but serious adverse events such as medullary thyroid carcinoma (boxed warning

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For example, the combination of the cancer drug Dasatinib and the natural compound Quercetin was shown to induce apoptosis in senescent cells in a variety of contexts in vitro and in vivo 1,4

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