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10.1186/1477-7827-1-30 21 LiX.LiJ.ZhaoQ.QiaoL.WangL.YuC

Dual Mechanism of Action: Unlike traditional GLP-1 medications that only act on the GLP-1 receptor, Mounjaro (tirzepatide) also acts on GIP receptors, enhancing insulin release and offering greater effects on blood sugar control and weight loss

Lifestyle interventions were the least effective treatment, the investigators found, producing a mean total body weight loss of 7.4% at the end of the treatment period, followed by a mean per-month weight regain of 0.14%, with participants reaching their pre-intervention weights within 4.1 years

It acts on appetite/satiety centres, helping to reduce food intake and supporting adherence to body recomposition strategies

Tendons and ligaments remodel slowly, even when pain is improving

Freeman, MD, PhD