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Refrigeration dramatically extends unopened shelf life by slowing hydrolysis kinetics according to the Arrhenius equation: every 10C temperature drop roughly halves the degradation rate

30-50g total fat daily minimum

Medication Overuse Headache Overuse of acute migraine drugs (e.g., ergotamines, triptans, opioids, or a combination of these drugs for 10 or more days per month) may lead to exacerbation of headache (i.e., medication overuse headache)

[2] Nevertheless, the principle of taking supplements only when clinically indicated remains important

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