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This may be due to the limited temporal window of our MRS measurements or could indicate that downstream mechanisms, such as AMPA receptor activation, neuroplastic signaling pathways (for example, BDNF or TrkB and ERK or mTOR) or effects in regions beyond the ACC, are more critical targets for mediating antidepressant response

25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

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Tsuchida KI, Taneda S, Yokota I, et al