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Activation of these enzymes under pathological conditions increases the levels of ROS, which in turn activate several cellular signaling factors such as nuclear factorB (NF-B), MAPK, Akt/PKB and tyrosine kinases

This heightened oxidative stress has led to interest in antioxidants like glutathione, which plays a vital role in neutralizing harmful free radicals

Because it increases ROS production and lowers antioxidant levels, excessive iodine consumption is considered an additional risk factor for developing AITD

35 In China the frequency of G6PD deficiency in males ranges from 0% to 17.4%, with the highest prevalence being seen in ethnic groups geographically related to historical malaria

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