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Chen PH, Tsuang FY, Lee CT, Yeh YC, Cheng HL, Lee TS, et al

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We used the cryo-EM structure of the FBXO22-UNC10088 C -NSD2 complex to prepare 3 different systems in addition to one already published structure of FBXO22-BACH1 (PDB: 8UA6) 13 , leading to a total of four FBXO22 configurations, such as FBXO22 alone, FBXO22-UNC10088 C , FBXO22-UNC10088 C -NSD2, and FBXO22-BACH1

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In stroke and chronic inflammation, HIF-1 is stabilized downstream of NF-B activation