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However, there are factors that have been linked to the development of Tietze's syndrome: Physical exertion

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Furthermore, Vitamin D 3 promotes autophagy ( 2 D 3 enhances the Sirtuin 3 (SIRT3)-Superoxide Dismutase 2 (SOD2) pathway, ameliorating mitochondrial oxidative stress and reducing mitochondrial reactive oxygen species (mtROS) accumulation, thereby indirectly inhibiting NLRP3 inflammasome activation ( 4.3 Nrf2 signaling pathway VDR activation downregulates Kelch-like ECH-associated protein 1 (Keap1, Nrf2s cytoplasmic inhibitor), promoting Nrf2 nuclear translocation and activation of antioxidant response elements ( Figure 2C )