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Ji L et al (2020) Deep sequencing shows that accumulation of potentially pathogenic mtDNA mutations rather than mtDNA copy numbers may be associated with early embryonic loss

There is a further action that the reduction of HOX transcript antisense RNA (HOTAIR) expression gives rise to cardiomyopathy

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Standard assays containing 0.2 M MSA-DH or MDH in 300 L buffer 1 containing 20 mM NAD(P) + were performed in the presence of 0.512 or 20 mM of the respective substrate MSA or D-malate