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It is a nonessential amino acid, meaning it is produced in sufficient quantities by the body if sufficient amounts of other nutrients are consumed

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A two-year carcinogenicity study was conducted in male and female rats given oral doses of sitagliptin of 50, 150, and 500 mg/kg/day

In cases with neoplastic lesions, mice with Grade 3 or 4 lesions were categorized as death by neoplastic disease