The glutaminase inhibitor CB-839 (Telaglenastat) enhances the antimelanoma activity of t-cell-mediated immunotherapies
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For example, DNA strand breaks and reversible cross-links with DNA or histone proteins of nucleosome core particles from AP sites affect transcription and replication in cells, further inducing gene mutations, which may cause apoptosis or cell carcinogenesis [19, 20]
However, we found each of these variables to significantly alter quantified glutathione levels
Hooda, Z, Werner, R, Ries, S, Eisenberg, M, Hofstetter, WL, Mehran, RJ, Rajaram, R, Rice, DC, Swisher, SG , Vaporciyan, AA, Walsh, GL, Opitz, I, Mitchell, KG, Antonoff, MB
After washing and resuspending, flow cytometry analysis was performed