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Butsch suggests the following

Gradual dose escalation is necessary to build efficacy and allow patients to reach the higher maintenance doses safely while managing tolerability

Improvements in liver function markers and lipid profiles were observed, suggesting comprehensive metabolic benefits that extend cardiovascular and hepatic protection

PQQ also increased average MMP values in cardiomyocytes and alleviated hypertrophy-associated changes in mitochondrial morphology consistent with its ability to restore mitochondrial homeostasis

Mechanism of Action: Same Biology as GLP-1 Drugs GLP-1 medications like Ozempic work by directly binding to GLP-1 receptors throughout the body in the brain, pancreas, and stomach producing sustained, maximal receptor activation that reduces appetite and regulates blood sugar