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Usp8, identified as rhythmically expressed in the Drosophila brain and more specifically clock neurons, directly deubiquitinates Clock to suppress its transcriptional activity within the Clock-cycle complex, thereby reducing expression of target genes like per and tim (McDonald and Rosbash, 2001

In instances where a patients age was recorded as less than 0 or greater than 120, the value was corrected by referring to previous clinical records or the record was excluded from the dataset if deemed unreliable

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