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10.1074/jbc.M700885200 70 LuW.CheX.QuX.ZhengC.YangX.BaoB.et al (2021)
Dysregulation of Bgn expression can result in a wide range of clinical conditions such as metabolic disorder, inflammatory disorder, musculoskeletal defects, and malignancies ( Mitogen-activated protein kinase activated protein kinase 3 is a member of the Mapk signaling pathway family ( Bgn gene can upregulate p38Mapk ( Conclusion In summary, we screened out the key differential genes that affect feeding behavior after GLP-1R activation through bioinformatics analysis
By targeting the GHS-R1a (ghrelin) receptor, it triggers growth hormone release without the spillover effects on other pituitary hormones seen with less refined compounds
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Residues forming the hydrophobic pocket are displayed in pink, the Phe residue that moves between the open and closed conformation is displayed in orange
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