Hypothyroidism, insulin resistance, obstructive sleep apnea, and medications such as corticosteroids can contribute to weight loss stabilization and persistent hyperglycemia
We did not find a significant linear relationship between dose (g/day) (coefficients = 0.09, p = 0.652) and duration (weeks) of intervention (coefficients = 2.68, p = 0.433) and changes in HOMA-IR (Figures 6D, 7D)
Importantly, such variability does not negate biological relevance, but rather underscores the challenge of translating dynamic, context-sensitive endocrine signals into static biomarkers
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Early treatment can help prevent symptoms from becoming more severe and disruptive over time