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Nilotinib is an orally available inhibitor of the BCR-ABL kinase and works by preventing the growth and proliferation of cancer cells, in turn inducing their death

This susceptibility is compounded by impaired redox homeostasis and multiple pathogenic factors: i) dysfunctional protein clearance mechanisms involving PTEN-induced kinase 1 (PINK1), Parkin, and -synuclein proteostasis

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In the pediatric clinical study, pediatric patients with type 1 diabetes had a higher incidence of severe symptomatic hypoglycemia compared to the adults in studies with type 1 diabetes [see Adverse Reactions (6.1)]

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First, following the principles of trial emulation, we outlined the protocol of the target trial and detailed emulation steps using Medicare data