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[57] Approval of the original brand-name versions (such as Ozempic) was based on a biologic (recombinant DNA) production process using a genetically-modified yeast ( Saccharomyces cerevisiae ) to produce a precursor to semaglutide, and subsequent chemical processes (protein purification) to create the active ingredient

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Research from the STEP clinical trial program demonstrated that weight loss outcomes were dose-dependent, with significantly greater reductions at higher doses

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Through H&E staining and Masson staining, we can see that, compared with normal mice, IUA mice have morphological destruction and continuity interruption of the endometrium, a significant reduction in the number of glands, and a significant increase in collagen fiber deposition