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Oxidative stress is at the root of myriad chronic illnesses

10.1021/tx500284g 44 LedentP.DuezC.VanhoveM.LejeuneA.Fonz,E.CharlierP.et al

Proceedings of the Society for Experimental Biology and Medicine

4 Immunopharmacological implications Physiological levels of ROS, which are present in all living organisms, can activate both signaling pathways such as MAPK and ERK and transcription factors such as NF-B ( However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Figure 3)

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