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Orforglipron (Orfoglip), approved in 2025, is an oral GLP-1 agonist for obesity

Depending on the brand, dose, and local prescribing guidance, semaglutide may also be prescribed for long-term weight management in adults with obesity or overweight with weight-related health conditions

A growing number of large employers are dropping GLP-1 coverage for weight loss heading into 2027, driven by climbing overall health care costs, even as per-unit drug prices have fallen

Distinct identity of GLP-1R, GLP-2R, and GIPR expressing cells and signaling circuits within the gastrointestinal tract