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Beyond serving as substrates, KBs and ketogenic diets (KD) may enhance mitochondrial function by promoting mitochondrial biogenesis via NAD-dependent signalling pathways involving SIRT1/2/3, AMPK, PGC-1, and FOXO1/3a, and by increasing mitochondrial respiration through PGC-1mediated effects on respiratory complexes (e.g., complex I/II)

The main confirmed actions were documented as: stimulating insulin secretion (incretin effect), inhibiting glucagon secretion, inhibiting gastrointestinal motility and secretion (enterogastrone / ileal brake mechanism), and regulating appetite and food intake

Multi-Omics analysis reveals the protection of gasdermin D in Concanavalin A-Induced autoimmune hepatitis

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