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Reproducibility values were lower for (a) GSH compared to metabolites easier to detect, such as N-acetylaspartate, myo-inositol, and total choline and creatine (Bednak et al., 2015, Lally et al., 2016, Reid et al., 2022, Schubert et al., 2017, van de Bank et al., 2015), (b) MEGA-PRESS relative to non-edited sequences (e.g., SPECIAL, PRESS, PR-STEAM) with short TEs (Dhamala et al., 2019, Wijtenburg et al., 2019), and (c) HERMES (TE = 80 ms) relative to MEGA-PRESS using a TE optimized for GSH measurement (TE = 120 ms) (Prisciandaro et al., 2020)

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Glutathione and mitochondria, 2014 Mitochondrial ROS generation and antioxidant defense systems