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We thank Dr Raymond Thomas (postdoctoral fellow) for published data on brain lipids and Drs Stephan Kahler and Anirudh Saronwala for their insight into propionic metabolism

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While the study had a large sample size and underwent manual review by experienced neuro-ophthalmologists, additional research, such as larger multicenter studies or prospective clinical trials, is required to confirm findings and explore causality

Immunofluorescence staining Fibroblasts were fixed, permeabilised, blocked, and incubated overnight at 4 C with primary antibodies targeting p53-pS15 and FOXO4 shown in Table 2, and developed using Alexa Fluor 488-conjugated donkey anti-mouse immunoglobulin G (1:100

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