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The intrinsic pathway is triggered by diverse intracellular stresses, such as DNA damage, metabolic perturbations, or endoplasmic reticulum stress, leading to mitochondrial outer membrane permeabilization (MOMP)

Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice

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Although SHY allows for some synapses to become stronger during sleep, this occurs under special (e.g., non-physiological) conditions, and therefore is not a major aspect of SHY (Tononi and Cirelli, 2014)